The 2-Minute Rule for megatomi.com
The 2-Minute Rule for megatomi.com
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Our new Obvious+ tissue clearing approach is the only technique that delipidates samples without modify in morphology and with nominal impact on structural integrity.
Megatome can be a vibrating microtome intended to segment a broad selection of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With high blade vibrating frequency and minimized blade deflection, Megatome permits substantial-throughput tissue sectioning with uniform surface area profile, as well as small tissue harm and knowledge loss.
Antibodies may possibly take months to diffuse by way of only a few millimeters of tissue, using a steep labeling gradient from area to core.
Megatome is suitable for accuracy: the blade vibrates at an increased frequency and larger amplitude array than other microtomes, and incorporates a distinctive deflection Regulate mechanism.
SE uses a rotational electrical subject to disperse highly electromobile molecules (including antibodies or surfactant micelles) in the course of a porous sample without harmful electrically charged buildings inside the tissue. This enables two-four working day clearing of intact organs,
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Megatome is really a novel microtome that allows for top-precision sectioning of a variety of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with nominal tissue injury and information decline.
It’s time and energy to upgrade your microtome to Megatome. With correct high-frequency slicing for an unmatched number of sample measurements and types – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for varied programs.
Totally delipidate complete mouse brains or comparably sized samples in only one day with SmartBatch+, or in a single week with our passive clearing package.
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Protect avoids the variability of hydrogel embedding and the knowledge reduction from PFA preservation, shielding specimens for multiple rounds of processing.
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Our novel SHIELD tissue preservation method types intramolecular bonds making use of polyfunctional, versatile epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.